GSK2636771
货号：
17380-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 17380-500ug |
| 描述 | Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol-3,4-bisphosphate (PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3). Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are four isoforms (p110α, p110β, p110δ, and p100γ), and a p85 regulatory subunit. GSK2636771 is an orally bioavailable inhibitor of PI3K p110β.1 At 1-10 µM, it decreases cell viability and Akt phosphorylation in p100β-dependent PTEN-deficient PC-3 prostate and BT549 and HCC70 breast cancer cell lines.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rivero, R.A., and Hardwicke, M.A. Abstract 2913: Identification of GSK263771, a potent and selective, orally bioavailable inhibitor of the phosphatidylinositol 3-kinaseβ(PI3Kα) for the treatment of PTEN deficient tumors. Cancer Research 72, 2913-2913 (2012).
2.Weigelt, B.,Warne, P.H.,Lambros, M.B., et al. PI3K pathway dependencies in endometrioid endometrial cancer cell lines. Clinical Cancer Research 19(13), 3533-3544 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 433.4 |
| 分子式 | C22H22F3N3O3 |
| CAS号 | 1372540-25-4 |
| 稳定性 | ≥ 2 years |
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