ML-240
货号：
17373-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17373-1mg |
| 描述 | ML-240 is an ATP-competitive inhibitor of the D2 domain of the ATPase p97 (IC50 = 0.11 µM; Ki = 0.22 µM).1,2 It disrupts the endoplasmic reticulum-associated degradation (ERAD) and autophagy pathways, preventing the degradation of p97-dependent proteasome substrates (IC50 = 0.9 µM) and causing accumulation of ubiquitin conjugates in nuclear membrane and cytosolic compartments at 5-10 µM.1 ML-240 has also been shown to block proliferation of HCT15 and SW403 colon cancer cell lines (GI50s = 0.76 and 0.5 µM, respectively) and to rapidly mobilize caspase-3 and -7, inducing apoptosis.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chou, T.F.,Li, K.,Frankowski, K.J., et al. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8(2), 297-312 (2013).
2.Chou, T.F.,Bulfer, S.L.,Weihl, C.C., et al. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. Journal of Molecular Biology 426(15), 2886-2899 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 396.4 |
| 分子式 | C23H20N6O |
| CAS号 | 1346527-98-7 |
| 稳定性 | ≥ 2 years |
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