Picropodophyllotoxin
货号：
17329-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17329-1mg |
| 描述 | Picropodophyllotoxin (PPP) is a potent and selective inhibitor of the insulin-like growth factor-1 receptor (IGF-1R), blocking the phosphorylation of artificial substrates with an IC50 value of 6 nM.1 It does not block substrate phosphorylation by insulin receptor, EGFR, FGFR, or PDGFR. PPP inhibits IGF-1R autophosphorylation (IC50 = ~1 nM), causes cell cycle arrest in G2/M phase, and induces apoptosis.1,2 It is orally active and causes complete tumor regression in xenografted and allografted mice.1 Presumably through its effect on IGF-1R, PPP reduces VEGF expression and suppresses choroidal neovascularization in vivo.3 |
| 别名 | AXL 1717;NSC 36407;Picropodophyllin;PPP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Girnita, A.,Girnita, L.,del Prete, F., et al. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 64(1), 236-242 (2004).
2.Strömberg, T.,Ekman, S.,Girnita, L., et al. IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 107(2), 669-678 (2006).
3.Economou, M.A.,Wu, J.,Vasilcanu, D., et al. Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor. Invest. Opthalmol. Vis. Sci. 49(6), 2620-2626 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 414.4 |
| 分子式 | C22H22O8 |
| CAS号 | 477-47-4 |
| 稳定性 | ≥ 2 years |
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