Mirabegron
货号：
17319-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 17319-500ug |
| 描述 | Mirabegron is a β3-adrenergic receptor agonist (EC50 = 22.4 nM) that displays potent selectivity for β3 compared to the β1 and β2 receptor subtypes (EC50s ≥ 10 µM).1 It has been shown to relax rat and human bladder strips precontracted with carbamoylcholine (Item No. 14486) with EC50 values of 5.1 and 0.78 µM, respectively.1 Clinical trials have supported the efficacy of mirabegron in overactive bladder therapy.2 |
| 别名 | YM-178; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Takasu, T.,Ukai, M.,Sato, S., et al. Effect of (R)-2-(2-aminothiazol-4-yl)-4-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective β3-adrenoceptor agonist, on bladder function. Journal of Pharmacology and Experimental Therapeutics 321(2), 642-647 (2007).
2.Sacco, E., and Bientinesi, R. Mirabegron: A review of recent data and its prospects in the management of overactive bladder. Ther.Adv.Urol. 4(6), 315-324 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 396.5 |
| 分子式 | C21H24N4O2S |
| CAS号 | 223673-61-8 |
| 稳定性 | ≥ 2 years |
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