| 货号 | 17277-500ug |
| 描述 | Secreted phospholipases A2(sPLA2s) are a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions.1 The group IIA sPLA2(sPLA2-IIA) was originally purified from platelets and exudates from patients with rheumatoid arthritis.1 Its expression can be induced by inflammatory mediators, and mouse studies suggest that it may play roles in colorectal polyposis, atherosclerosis, and bacterial infections.1,2sPLA2 inhibitor is an orally active inhibitor of sPLA2-IIA.3 It protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally.3sPLA2 inhibitor also attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats.4,5 |
| 别名 | KH064;Secretory Phospholipase A2Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Murakami, M.,Taketomi, Y.,Miki, Y., et al. Recent progress in phospholipase A2 research: From cells to animals to humans. Progress in Lipid Research 50(2), 152-192 (2011). 2.Murakami, M.,Taketomi, Y.,Girard, C., et al. Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice. Biochimie 92(6), 561-582 (2010). 3.Arumugam, T.V.,Arnold, N.,Proctor, L.M., et al. Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology 140(1), 71-80 (2003). 4.Yu, J.A.,Kalatardi, S.,Dohse, J., et al. Group IIa sPLA2 inhibition attenuates NF-κB activity and promotes apoptosis of lung cancer cells. Anticancer Research 32(9), 3601-3607 (2012). 5.Iyer, A.,Lim, J.,Poudyal, H., et al. An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. Diabetes 61(9), 2320-2329 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 487.6 |
| 分子式 | C31H37NO4 |
| CAS号 | 393569-31-8 |
| 稳定性 | ≥ 2 years |
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