| 货号 | 17178-1mg |
| 描述 | 1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 µM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome.1,2 By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vallee, F.,Karaveg, K.,Herscovics, A., et al. Structural basis for catalysis and inhibition of N-glycan processing class I α1,2-mannosidases. The Journal of Biological Chemisty 275(52), 41287-41298 (2000). 2.Bischoff, J.,Liscum, L., and Kornfeld, R. The use of 1-deoxymannojirimycin to evaluate the role of various α-mannosidases in oligosaccharide processing in intact cells. The Journal of Biological Chemisty 261(10), 4766-4774 (1986). 3.Balzarini, J. The α(1,2)-mannosidase I inhibitor 1-deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120. FEBS Letters 581(10), 2060-2064 (2007). 4.Ogier-Denis, E.,Trugnan, G.,Sapin, C., et al. Dual effect of 1-deoxymannojirimycin on the mannose uptake and on the N-glycan processing of the human colon cancer cell line HT-29. The Journal of Biological Chemisty 265(10), 5366-5369 (1990). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 199.6 |
| 分子式 | C6H13NO4 • HCl |
| CAS号 | 73465-43-7 |
| 稳定性 | ≥ 2 years |
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