ARN-509
货号：
17132-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17132-1mg |
| 描述 | ARN-509 is an antagonist of the androgen receptor (IC50 = 16 nM).1 It binds the receptor but does not cause nuclear localization or DNA binding.1 ARN-509 is orally bioavailable and, at 30 mg/kg/d, suppresses tumor growth in a mouse model of castration-resistant prostate cancer.1 This compound can be used to study androgen signaling in vitroandin vivo and has potential applications in certain types of cancer.2 |
| 别名 | JNJ-56021927; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Clegg, N.J.,Wongvipat, J.,Joseph, D.J., et al. ARN-509: A novel antiandrogen for prostate cancer treatment. Cancer Research 72(6), 1494-1503 (2012).
2.Gupta, E.,Guthrie, T., and Tan, W. Changing paradigms in management of metastatic Castration Resistant Prostate Cancer (mCRPC). BMC Urol. 14, 1-8 (2014).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 477.4 |
| 分子式 | C21H15F4N5O2S |
| CAS号 | 956104-40-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
