| 货号 | 17126-1mg |
| 描述 | CGS 21680 is a potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM).1,2 It is less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B(Ki > 10 µM).2,3,4,5 CGS 21680 is commonly used to study the actions of the adenosine A2A receptor in cells and tissues.6,7,8 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ji, X.d.,Gallo-Rodriguez, C., and Jacobson, K.A. A selective agonist affinity label for A3 adenosine receptors. Biochemical and Biophysical Research Communications 203(1), 570-576 (1994). 2.Kim, H.O.,Ji, X.d.,Siddiqi, S.M., et al. 2-Substitution of N6-benzyladenosine-5-uronamides enhances selectivity for A3 adenosine receptors. Journal of Medicinal Chemistry 37(21), 3614-3621 (1994). 3.Klotz, K.-N.,Hessling, J.,Hegler, J., et al. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedebergs Arch. Pharmacol. 357, 1-9 (1998). 4.Linden, J.,Thai, T.,Figler, H., et al. Characterization of human A2B adenosine receptors: Radioligand binding, western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular Pharmacology 56(4), 705-713 (1999). 5.Varani, K.,Merighi, S.,Gessi, S., et al. [3H]MRE 3008F20: A novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptors. Molecular Pharmacology 57(5), 968-975 (2000). 6.Cheng, M.K.,Doumad, A.B.,Jiang, H., et al. Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat prelomerular microvessels (PGMV) via A2A receptors. British Journal of Pharmacology 141, 441-448 (2004). 7.Ledent, C.,Vaugeois, J.M.,Schiffmann, S.N., et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2A receptor. Nature 388, 674-678 (1997). 8.Gnad, T.,Scheibler, S.,von Kügelgen, I., et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 536 |
| 分子式 | C23H29N7O6 • HCl |
| CAS号 | 124431-80-7 |
| 稳定性 | ≥ 2 years |
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