SR8278
货号：
17000-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17000-1mg |
| 描述 | REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner.1,2 SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112 (Item No. 11931).2 Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells.2 SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Duez, H., and Staels, B. Rev-erb-α: An integrator of circadian rhythms and metabolism. Journal of Applied Physiology 107(6), 1972-1980 (2009).
2.Kojetin, D.,Wang, Y.,Kameneck, T.M., et al. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chemical Biology 6(2), 131-134 (2011).
3.Vieira, E.,Marroquí, L.,Figueroa, A.L., et al. Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells. PLoS One 8(7), 1-15 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 361.5 |
| 分子式 | C18H19NO3S2 |
| CAS号 | 1254944-66-5 |
| 稳定性 | ≥ 1 year |
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