Dabrafenib
货号：
16989-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 16989-5mg |
| 描述 | Dabrafenib is a selective inhibitor of mutant B-RafV600E(IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50s = 3.2 and 5 nM, respectively).1 It has been investigated in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors and is often combined with the MEK inhibitor trametinib (Item No. 16292) to circumvent the development of B-Raf inhibitor resistance.1 |
| 别名 | GSK2118436; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, T.,Karsy, M.,Zhuge, J., et al. B-Raf and the inhibitors: From bench to bedside. J.Hematol.Oncol. 6, 1-9 (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 519.6 |
| 分子式 | C23H20F3N5O2S2 |
| CAS号 | 1195765-45-7 |
| 稳定性 | ≥ 2 years |
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