AZD 8055
货号：
16978-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16978-1mg |
| 描述 | AZD 8055 is a potent, selective ATP-competitive inhibitor of mTOR, exhibiting an IC50 value of 0.8 nM.1 It is ~1,000-fold selective for mTOR over all PI3K isoforms and exhibits no activity against a panel of 260 kinases at concentrations up to 10 µM. AZD 8055 inhibits proliferation of A549 and H838 cells with IC50 values of 53 and 20 nM, respectively. It inhibits growth of a variety of human tumor xenografts by at least 65% in mice at daily oral doses of 20 mg/kg.1 |
| 别名 | CCG-168; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chresta, C.M.,Davies, B.R.,Hickson, I., et al. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Research 70(1), 288-298 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 465.5 |
| 分子式 | C25H31N5O4 |
| CAS号 | 1009298-09-2 |
| 稳定性 | ≥ 2 years |
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