ZM 306416
货号：
16968-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 16968-500ug |
| 描述 | ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase that antagonizes the activity of KDR and Flt VEGF receptors with IC50 values of 100 nM and 2 μM, respectively.1 It has also been reported to inhibit EGFR kinase with an IC50 value of < 10 nM, reducing proliferation of EGFR-dependent cancer cells.2 |
| 别名 | CB-676475; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hennequin, L.F.,Thomas, A.P.,Johnstone, C., et al. Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. Journal of Medicinal Chemistry 42(26), 5369-5389 (1999).
2.Antczak, C.,Mahida, J.P.,Bhinder, B., et al. A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: Implications in drug discovery. Journal of Biomolecular Screening 17(7), 885-899 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 333.7 |
| 分子式 | C16H13ClFN3O2 |
| CAS号 | 690206-97-4 |
| 稳定性 | ≥ 2 years |
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