| 货号 | 16937-25mg |
| 描述 | 1-methyl Adenosine is a modified nucleoside generated by the processing of tRNA by methyltransferases.1,2,3 The urinary excretion of 1-methyl adenosine is elevated in several forms of cancer, supporting its use as a biomarker in early detection.4,5,6 It can also be monitored in serum.7 Urinary levels of 1-methyl adenosine also increase during active rheumatoid arthritis.8 |
| 别名 | 1-methyl Ado;NSC 92165; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Munns, T.W., and Sims, H.F. Methylation and processing of transfer ribonucleic acid in mammalian and bacterial cells. The Journal of Biological Chemisty 250(6), 2143-2149 (1975). 2.Vold, B. Modified nucleosides of Bacillus subtilis transfer ribonucleic acids. Journal of Bacteriology 127(1), 258-267 (1976). 3.Chujo, T., and Suzuki, T. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. RNA 18(12), 2269-2276 (2012). 4.Reynaud, C.,Bruno, C.,Boullanger, P., et al. Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies. Cancer Letters 255-262 (1991). 5.Seidel, A.,Brunner, S.,Seidel, P., et al. Modified nucleosides: An accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control. British Journal of Cancer 94(11), 1726-1733 (2006). 6.Hsu, W.Y.,Chen, C.J.,Huang, Y.C., et al. Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. PLoS One 8(12), 1-8 (2013). 7.Chen, F.,Xue, J.,Zhou, L., et al. Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method. Analytical and Bioanalytical Chemistry 401(6), 1899-1904 (2011). 8.Tebib, J.G.,Reynaud, C.,Cedoz, J.P., et al. Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process. British Journal of Rheumatology 36(9), 990-995 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 281.3 |
| 分子式 | C11H15N5O4 |
| CAS号 | 15763-06-1 |
| 稳定性 | ≥ 2 years |
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