BRL 50481
货号:
16899-5mg 基本售价:
490.0 元 规格:
5 mg
产品信息
概述货号 | 16899-5mg |
描述 | BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM.1 It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5.1 Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects of the PDE4 blocker rolipram (Item No. 10011132) on monocytes, lung macrophages, and CD8+T-lymphocytes.1 BRL 50481, at 30 µM, promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B, suggesting that this compound also acts against PDE7B.2 BRL 50481 can be used to evaluate the role of PDE7 isoforms in intracellular signaling.3 |
性能供应商 | Cayman |
应用文献 |
1.Smith, S.J.,Cieslinski, L.B.,Newton, R., et al. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Molecular Pharmacology 66(6), 1679-1689 (2004). 2.Zhang, L.,Murray, F.,Zahno, A., et al. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 105(49), 19532-19537 (2008). 3.Zhai, K.,Hubert, F.,Nicolas, V., et al. β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7(10), 1-13 (2012).
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运输条件 | Room temperature in continental US; may vary elsewhere |
存放说明 | -20 |
纯度 | ≥98% |
计算分子量 | 244.3 |
分子式 | C9H12N2O4S |
CAS号 | 433695-36-4 |
稳定性 | ≥ 2 years |
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