P32/98 (hemifumarate)
货号：
16887-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16887-1mg |
| 描述 | The glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are responsible for a majority of nutrient-stimulated insulin secretion. After being released into the circulation, GIP and GLP-1 are inactivated by the circulating enzyme dipeptidyl peptidase IV (DPP IV). DPP IV inhibitors have emerged as a new class of experimental antidiabetic agents. P32/98 is a competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM).1 At 20 mg/kg/day, it has been used to improve glucose tolerance, insulin sensitivity, and β-cell glucose responsiveness in diabetic rat models.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Weber, A.E. Dipeptidyl peptidase IV inhibitors for the treatment of diabetes. Journal of Medicinal Chemistry 47(17), 4135-4141 (2004).
2.Pospisilik, J.A.,Stafford, S.G.,Demuth, H.U., et al. Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and β-cell glucose responsiveness in VDF (fa/fa) zucker rats. Diabetes 51, 943-950 (2002).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 260.4 |
| 分子式 | C9H18N2OS • 1/2C4H4O4 |
| CAS号 | 251572-86-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
