U-104
货号：
16717-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 16717-5mg |
| 描述 | Carbonic anhydrases are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form bicarbonate ion plus a proton. Carbonic anhydrases IX (CAIX) and CAXII are hypoxia and HIF-1-inducible proteins located in cellular transmembranes that regulate intra- and extracellular pH under hypoxic conditions and promote tumor cell survival and invasion in hypoxic microenvironments. U-104 is a ureido-sulfonamide inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM).1 It demonstrates reduced affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively).1 U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.1 |
| 别名 | NSC 213841; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lou, Y.,McDonald, P.C.,Oloumi, A., et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Research 71(9), 3364-3376 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 309.3 |
| 分子式 | C13H12FN3O3S |
| CAS号 | 178606-66-1 |
| 稳定性 | ≥ 2 years |
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