NSC 348884
货号：
16716-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16716-1mg |
| 描述 | Nucleophosmin is a nucleolar phosphoprotein involved in cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, centrosome duplication, and molecular chaperoning. Its activity is dependent on oligomerization at its N-terminal domain, and it is abundantly expressed in tumor and developing cells where it serves to inhibit both cellular differentiation and apoptosis.1 NSC 348884 is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a required binding pocket. It can inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Qi, W.,Shakalya, K.,Stejskal, A., et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene 27(30), 4210-4220 (2008).
2.Zhang, J.,Zhao, H.L.,He, J.f., et al. Inhibitory effect of NSC348884, a small molecular inhibitor of nucleophosmin, on the growth of hepatocellular carcinoma cell line hepG2. Zhongguo Yi Xue Ke Yuan Xue Bao 34(1), 58-61 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 636.8 |
| 分子式 | C38H40N10 |
| CAS号 | 81624-55-7 |
| 稳定性 | ≥ 2 years |
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