Celiprolol (hydrochloride)
货号：
16715-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16715-1mg |
| 描述 | Celiprolol is a β1 adrenergic receptor antagonist and a β2 adrenergic receptor partial agonist that has been shown to relax human arteries and veins with ED50 values of 40-50 µM in vitro.1 At 1-10 mg/kg/h, celiprolol can reduce myocardial infarct size and increase nitric oxide (NO) production in a rabbit model of myocardial ischemia.2 Furthermore, 100 mg/kg/d celiprolol has been reported to stimulate expression and activate phosphorylation of endothelial NO synthase in rat cardiac myocytes.3 |
| 别名 | Corliprol;NSC 324509; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hoffman, D.L. Mitochondria and cellular homeostatis: Beyond ATP synthesis. Mitochondrial Health 2014, 1-2 (2014).
2.Chen, X.,Minatoguchi, S.,Arai, M., et al. Celiprolol, a selective β1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarction. Circulation Journal 71(4), 574-579 (2007).
3.Liao, Y.,Asakura, M.,Takashima, S., et al. Celiprolol, a vasodilatory β-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice. Circulation 110(6), 692-699 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416 |
| 分子式 | C20H33N3O4 • HCl |
| CAS号 | 57470-78-7 |
| 稳定性 | ≥ 2 years |
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