SR 3677
货号：
16708-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16708-1mg |
| 描述 | SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK-II than ROCK-I in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively).1 At 3 µM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50% inhibition.1 SR 3677 is efficacious at inhibiting myosin light chain phosphorylation and increasing aqueous humor outflow in porcine eyes in an ex vivo model of glaucoma treatment.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Feng, Y.,Yin, Y.,Weiser, A., et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. Journal of Medicinal Chemistry 51(21), 6642-6645 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 408.5 |
| 分子式 | C22H24N4O4 |
| CAS号 | 1072959-67-1 |
| 稳定性 | ≥ 2 years |
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