Mozavaptan (hydrochloride)
货号：
16664-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 16664-5mg |
| 描述 | Mozavaptan is a benzazepine derivative that antagonizes the binding of arginine vasopressin (AVP) to vasopressin receptors located in the liver (V1; IC50 = 1.2 µM) and kidney (V2; IC50 = 14 nM).1 At 10-100 µg/kg, mozavaptan can inhibit the antidiuretic action of AVP, promoting aquaresis when administered intravenously to rats.1 The therapeutic potential of mozavaptan in ectopic antidiuretic hormone syndrome, heart failure, and other complications related to hyponatremia has been studied.2,3 |
| 别名 | OPC 31260; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yamamura, Y.,Ogawa, H.,Yamashita, H., et al. Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist. British Journal of Pharmacology 105(4), 787-791 (1992).
2.Ectopic, A.D.H.S.T.R.G.,Yamaguchi, K.,Shijubo, N., et al. Clinical implication of the antidiuretic hormone (ADH) receptor antagonist mozavaptan hydrochloride in patients with ectopic ADH syndrome. Japanese Journal of Clinical Oncology 41(1), 148-152 (2011).
3.Izumi, Y.,Miura, K. and Iwao, H. Therapeutic potential of vasopressin-receptor antagonists in heart failure. J. Pharmacol. Sci. 124(1), 1-6 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 464 |
| 分子式 | C27H29N3O2 • HCl |
| CAS号 | 138470-70-9 |
| 稳定性 | ≥ 2 years |
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