| 货号 | 16622-100mg |
| 描述 | Cyproterone acetate (CPA) is a synthetic steroid that acts as an antagonist/partial agonist of the androgen receptor (IC50 = 26 nM in humans).1 Androgen receptor antagonists such as CPA have been shown to have clinical use in androgen-dependent conditions such as prostate cancer, hirsutism, and alopecia.1,2 However, high doses of CPA (10 mg/animal/day) can suppress accessory sexual glands and fertility in adult male rats.3 CPA promotes hepatomitogenic activity and has been reported to induce apoptosis of hepatocytes in rats at 0.3 µM after 72 hours exposure.4,5 |
| 别名 | Androcur®;CPA;Cyprostat;NSC 81430;SH 714; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hamann, L.G.,Higuchi, R.I.,Zhi, L., et al. Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines. Journal of Medicinal Chemistry 41(4), 623-639 (1998). 2.Qiao, Y.,Wang, L.,Cai, L.Q., et al. Inhibition of aberrant androgen receptor induction of prostate specific antigen gene expression, cell proliferation and tumor growth by 17α-estradiol in prostate cancer. Journal of Urology 185(1), 305-314 (2011). 3.Steinbeck, H.,Mehring, M. and Neumann, F. Comparison of the effects of cyproterone, cyproterone acetate and oestradiol on testicular function, accessory sexual glands and fertility in a long-term study on rats. Journal of Reproduction and Fertility 26(1), 65-76 (1971). 4.Kasper, P. and Mueller, L. Sex-specific induction of apoptosis by cyproterone acetate in primary rat hepatocytes. Carcinogenesis 20(11), 2185-2188 (1999). 5.Oberhammer, F.A.,Pavelka, M.,Sharma, S., et al. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proceedings of the National Academy of Sciences of the United States of America 85(12), 5408-5412 (1992). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416.9 |
| 分子式 | C24H29ClO4 |
| CAS号 | 427-51-0 |
| 稳定性 | ≥ 2 years |
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