| 货号 | 16620-1mg |
| 描述 | Neuraminidases, also known as sialidases, catalyze the removal of N-acetylneuraminic acid/sialic acid groups from glycoproteins and glycolipids. In addition to having diverse roles in mammalian physiology, neuraminidases are involved in infection by pathogens, including influenza virus.1 Specifically, viral neuraminidases are essential for viral replication.2 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid (4-MUNANA) is a fluorogenic substrate used to assay neuraminidase activity.3 4-Methylumbelliferone, released from 4-MUNANA by neuraminidase, is commonly detected using excitation at 365-380 nm and emission at 445-454 nm.4 Assays using 4-MUNANA sensitively measure the activity of neuraminidases from mammalian and viral sources.5,6,7,8 |
| 别名 | 4-MUNANA;Neu5Ac-α-4MU;Sodium 2-(4-methylumbelliferyl)-N-acetylneuraminate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Elliott, M. Zanamivir: From drug design to the clinic. Philosophical Transactions of the Royal Society of London.Series B, Biological Sciences 356(1416), 1885-1893 (2001). 2.Davies, B.E. Pharmacokinetics of oseltamivir: An oral antiviral for the treatment and prophylaxis of influenza in diverse populations. Journal of Antimicrobial Chemotherapy 65 Suppl 2, ii5-ii10 (2010). 3.Matsuzaki, S.,Itakura, M.,Iwamura, K., et al. Neuraminidase activity in human peripheral lymphocytes: Its increase in chronic active liver disease. Jpn.J.Med. 23(2), 123-126 (1987). 4.Zhi, H.,Wang, J.,Wang, S., et al. Fluorescent properties of hymecromone and fluorimetric analysis of hymecromone in compound dantong capsule. J. Spectrosc. 2013, 1-9 (2014). 5.Monti, E.,Preti, A.,Nesti, C., et al. Expression of a novel human sialidase encoded by the NEU2 gene. Glycobiology 9(12), 1313-1321 (1999). 6.Stamatos, N.M.,Liang, F.,Nan, X., et al. Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. FEBS Journal 272(10), 2545-2556 (2005). 7.Cross, A.S.,Hyun, S.W.,Miranda-Ribera, A., et al. NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not. The Journal of Biological Chemisty 287(19), 15966-15980 (2012). 8.Wetherall, N.T.,Trivedi, T.,Zeller, J., et al. Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: Report of the neuraminidase inhibitor susceptibility network. Journal of Clinical Microbiology 41(2), 742-750 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 489.4 |
| 分子式 | C21H24NO11 • Na |
| CAS号 | 76204-02-9 |
| 稳定性 | ≥ 2 years |
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