Ryuvidine
货号：
16614-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16614-1mg |
| 描述 | SET domain-containing protein 8 (SETD8) is a methyltransferase that selectively monomethylates histone H4 at lysine residue 20 (H4K20), an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. Ryuvidine is an inhibitor of SETD8 (IC50 = 0.5 µM) that suppresses monomethylation of H4K20 in vitro.1 It less potently inhibits cyclin-dependent kinase 4 (Cdk4; IC50 = 6 µM for Cdk4/cyclin D1).2 Over several hours of treatment, ryuvidine suppresses the expression of cell division cycle 7-related kinase (Cdc7), resulting in an ATM-dependent checkpoint response and arrest of cell cycling in S phase.1,3 |
| 别名 | Cdk4 Inhibitor III;Cyclic-dependent Kinase 4 Inhibitor III;SPS812; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Blum, G.,Ibáñez, G.,Rao, X., et al. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chemical Biology 9(11), 2471-2478 (2014).
2.Ryu, C.K.,Kang, H.Y.,Lee, S.K., et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorganic & Medicinal Chemistry Letters 10, 461-464 (2000).
3.FitzGerald, J.,Murillo, L.S.,OBrien, G., et al. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9(6), (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 284.3 |
| 分子式 | C15H12N2O2S |
| CAS号 | 265312-55-8 |
| 稳定性 | ≥ 2 years |
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