FTase Inhibitor II
货号：
16607-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16607-1mg |
| 描述 | Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins.1,2 This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function at, membranes. FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras.3 It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM).3 FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.3 |
| 别名 | Farnesyltransferase Inhibitor II;FTI-II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Berndt, N.,Hamilton, A.D. and Sebti, S.M. Targeting protein prenylation for cancer therapy. Nature Reviews.Cancer 11(11), 775-791 (2011).
2.Appels, N.M.G.M.,Beijnen, J.H. and Schellens, J.H.M. Development of farnesyl transferase inhibitors: A review. Oncologist 10, 565-578 (2005).
3.Manne, V.,Ricca, C.S.,Brown, J.G., et al. Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. Drug Development Research 34, 121-137 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥80% |
| 计算分子量 | 371.5 |
| 分子式 | C15H21N3O4S2 |
| CAS号 | 156707-43-6 |
| 稳定性 | ≥ 2 years |
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