CHIR124
货号：
16553-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16553-1mg |
| 描述 | Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM in vitro).1 It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC50 = 0.7 µM).1 In synergy with topoisomerase I poisons or ionizing radiation, CHIR124 can inhibit the growth of p53-mutant solid tumor cells both in vitro and in a xenograft model, potentiating tumor apoptosis.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tse, A.N.,Rendahl, K.G.,Sheikh, T., et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clinical Cancer Research 13(2 Pt 1), 591-602 (2007).
2.Tao, Y.,Leteur, C.,Yang, C., et al. Radiosensitization by Chir-124, a selective CHK1 inhibitor: Effects of p53 and cell cycle checkpoints. Cell Cycle 8(8), 1196-1205 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 419.9 |
| 分子式 | C23H22ClN5O |
| CAS号 | 405168-58-3 |
| 稳定性 | ≥ 2 years |
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