Gimeracil
货号：
16525-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 16525-5mg |
| 描述 | 5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.1 Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.2 Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.3 |
| 别名 | CDHP;5-Chlorodihydropyrimidine;Gimestat; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wyatt, M.D. and Wilson, D.M., III. Participation of DNA repair in the response to 5-fluorouracil. Cell Mol.Life Sci. 66(5), 788-799 (2009).
2.Adjei, A.A. A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer. British Journal of Clinical Pharmacology 48(3), 265-277 (1999).
3.Sakata, K.I.,Someya, M.,Matsumoto, Y., et al. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Cancer Science 102(9), 1712-1716 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 145.5 |
| 分子式 | C5H4ClNO2 |
| CAS号 | 103766-25-2 |
| 稳定性 | ≥ 2 years |
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