| 货号 | 16482-1mg |
| 描述 | Epothilone A (Epo A) is a biologically active macrolide produced from the fermentation of the soil bacteria S. cellulosum that was discovered as a potent antimicrotubule agent.1,2,3 In competition assays, epo A binds to β-tubulin with a similar order of magnitude as the binding of paclitaxel (Item No. 10461) to β-tubulin (IC50s = 2.3 and 3.6 µM, respectively).1,2,3,4 Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B (Item No. 10924).1 |
| 别名 | Epo A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cheng, K.L.,Bradley, T. and Budman, D.R. Novel microtubule-targeting agents - the epothilones. Biologics 2(4), 789-811 (2008). 2.Bollag, D.M.,McQueney, P.A.,Zhu, J., et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Research 55(11), 2325-2333 (1995). 3.Goodin, S.,Kane, M.P. and Rubin, E.H. Epothilones: Mechanism of action and biologic activity. Journal of Clinical Oncology 22(10), 2015-2025 (2011). 4.Kowalski, R.J.,Giannakakou, P. and Hamel, E. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). The Journal of Biological Chemisty 272(4), 2534-2541 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 493.7 |
| 分子式 | C26H39NO6S |
| CAS号 | 152044-53-6 |
| 稳定性 | ≥ 2 years |
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