| 货号 | 16473-5g |
| 描述 | Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid.1,2 Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).2 Trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, has long been used against urinary tract infections.3 It may also have prophylactic applications, for example in patients receiving biologic agents during inflammation.4 |
| 别名 | Trimpex; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lam, T.,Hilgers, M.T.,Cunningham, M.L., et al. Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines. Journal of Medicinal Chemistry 57(3), 651-668 (2014). 2.Schweitzer, B.I.,Dicker, A.P. and Bertino, J.R. Dihydrofolate reductase as a therapeutic target. The FASEB Journal 4(8), 2441-2452 (1990). 3.Brodgen, R.N.,Carmine, A.A.,Heel, R.C., et al. Trimethoprim: A review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs 23(6), 405-430 (1982). 4.Bodro, M. and Paterson, D.L. Has the time come for routine trimethoprim-sulfamethoxazole prophylaxis in patients taking biologic therapies? Clinical Infectious Diseases 56(110), 1621-1628 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 290.3 |
| 分子式 | C14H18N4O3 |
| CAS号 | 738-70-5 |
| 稳定性 | ≥ 2 years |
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