RHC-80267
货号：
16432-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 16432-5mg |
| 描述 | Diacylglycerol (DAG) is an important cellular source of arachidonic acid (Item No. 90010) which may be released by the action of DAG lipase. RHC-80267 is a selective inhibitor of DAG lipase (IC50 = 4 µM in canine platelets) that demonstrates relatively weak inhibition of phospholipases A2 and C.1 By elevating the concentration of diacylglycerol, RHC-80267 is thought to initiate activation of protein kinase C.2 At 0.3-1 µM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation in vitro.2 |
| 别名 | U-57908; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sutherland, C.A. and Amin, D. Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267. The Journal of Biological Chemisty 257(23), 14006-14010 (2014).
2.Suzuki, H.,Kito, Y.,Fukuta, H., et al. Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum. Journal of Smooth Muscle Research 38(6), 153-164 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 394.5 |
| CAS号 | 83654-05-1 |
| 稳定性 | ≥ 2 years |
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