NSC 66811
货号：
16431-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16431-1mg |
| 描述 | NSC 66811 is a potent inhibitor of murine double minute 2 (Mdm2) interaction with p53 by binding Mdm2 (Ki = 120 nM), in this way activating p53.1 NSC 66811 induces the accumulation of p21, p53, and Mdm2 in human colon cancer cells in vitro. Inhibitors of the Mdm2-p53 interaction, including NSC 66811, induce p53- and p21-dependent cell cycle arrest and p53-dependent cell death in tumor cell lines.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lu, Y.,Nikolovska-Coleska, Z.,Fang, X., et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. Journal of Medicinal Chemistry 49(13), 3759-3762 (2006).
2.Shangary, S. and Wang, S. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: A novel approach for cancer therapy. Annual Reviews of Pharmacology and Toxicology 49, 223-241 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 340.4 |
| 分子式 | C23H20N2O |
| CAS号 | 6964-62-1 |
| 稳定性 | ≥ 2 years |
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