β-Nicotinamide Mononucleotide
货号：
16411-10mg 基本售价：
490.0 元 规格：
10 mg
产品信息
概述| 货号 | 16411-10mg |
| 描述 | β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+; Item No. 16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.1 At 50-100 µM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.2 Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+levels.3 |
| 别名 | β-NMN; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gallí, M.,Van Gool, F.,Rongvaux, A., et al. The nicotinamide phosphoribosyltransferase: A molecular link between metabolism, inflammation, and cancer. Cancer Research 70, 8-11 (2010).
2.Revollo, J.R.,Körner, A.,Mills, K.F., et al. Nampt/PBEF/visfatin regulates insulin secretion in Β cells as a systemic NAD biosynthetic enzyme. Cell Metabolism 6(5), 363-375 (2007).
3.Yoshino, J.,Mills, K.F.,Yoon, M.J., et al. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism 14, 528-536 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 334.2 |
| 分子式 | C11H15N2O8P |
| CAS号 | 1094-61-7 |
| 稳定性 | ≥ 2 years |
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