货号 | 16348-10mg |
描述 | Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5’ to the abasic site to produce a single strand break.1 DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 µM).1,2,3 Although not toxic to cells by itself at 200 µM, it enhances the cytotoxicity of certain DNA alkylating agents, including temozolomide, when added at this concentration.2 DNA base excision repair pathway inhibitor has little or no effect on radiation-induced cell survival.2,4 |
别名 | CRT0044876;7-Nitroindole-2-Carboxylic Acid;NSC 69877; |
供应商 | Cayman |
应用文献 | |
1.Srinivasan, A.,Wang, L.,Cline, C.J., et al. Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors. Biochemistry 51(31), 6246-6259 (2012). 2.Madhusudan, S.,Smart, F.,Shrimpton, P., et al. Isolation of a small molecule inhibitor of DNA base excision repair. Nucleic Acids Research 33(15), 4711-4724 (2005). 3.Mohammed, M.Z.,Vyjayanti, V.N.,Laughton, C.A., et al. Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. British Journal of Cancer 104(4), 653-663 (2011). 4.Naidu, M.D.,Mason, J.M.,Pica, R.V., et al. Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1. J.Radiat.Res. 51(4), 393-404 (2010). | |
运输条件 | Room temperature in continental US; may vary elsewhere |
存放说明 | -20 |
纯度 | ≥98% |
计算分子量 | 206.2 |
分子式 | C9H6N2O4 |
CAS号 | 6960-45-8 |
稳定性 | ≥ 2 years |
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