| 货号 | 16338-1mg |
| 描述 | The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE.1 Alternatively, retinoid receptors interact with and modulate other transcription factors, including activator protein-1 (AP-1).1 SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE.2 It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 µM).3 SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fontana, J.A. and Rishi, A.K. Classical and novel retinoids: Their targets in cancer therapy. Leukemia 16(4), 463-472 (2002). 2.Fanjul, A.,Dawson, M.I.,Hobbs, P.D., et al. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372, 107-111 (1994). 3.Huang, C.,Ma, W.Y.,Dawson, M.I., et al. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proceedings of the National Academy of Sciences of the United States of America 94(11), 5826-5830 (1997). 4.Shiohara, M.,Dawson, M.I.,Hobbs, P.D., et al. Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 93(6), 2057-2066 (1999). 5.Kankaanranta, H.,Ilmarinen, P.,Zhang, X., et al. Tumour necrosis factor-α regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-κB and AP-1. PLoS One 9(2), 1-11 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 376.5 |
| 分子式 | C26H32O2 |
| CAS号 | 160162-42-5 |
| 稳定性 | ≥ 1 year |
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