Y320
货号：
16314-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16314-1mg |
| 描述 | IL-15 is a pro-inflammatory cytokine with roles in cancer and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, celiac disease, and alopecia areata.1 IL-15 can induce IL-17 production by CD4 T cells.2 Y320 is an inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody (IC50s = 57.4 and 25.7 nM, respectively).2 Oral administration of Y320 (0.3-3 mg/kg) reduces the expression of inflammatory cytokines, including IL-17, and inhibits joint destruction in type II collagen-induced arthritis (CIA) in mice.2 In this model, it acts synergistically with TNF-α monoclonal antibody in ameliorating arthritis and joint destruction scores.2 Y320 also significantly reduces joint swelling in cynomolgus monkey CIA.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Waldmann, T.A. The biology of IL-15: Implications for cancer therapy and the treatment of autoimmune disorders. J.Investig.Dermatol.Symp.Proc. 16(1), S28-S30 (2013).
2.Ushio, H.,Ishibuchi, S.,Oshita, K., et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel) 7(1), 1-17 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 505 |
| 分子式 | C27H29ClN6O2 |
| CAS号 | 288250-47-5 |
| 稳定性 | ≥ 2 years |
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