Dapivirine
货号：
16247-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16247-1mg |
| 描述 | Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of HIV-1 reverse transcriptase. Dapivirine, a diarylpyrimidine derivative of the potent NNRTI efavirenz (Item No. 14412), inhibits HIV-1 reverse transcriptase with an IC50 value of 24 nM in vitro.1 It impedes the late stages of HIV-1 infection by interfering with HIV-1 Gag-Pol polyprotein processing.2 |
| 别名 | R147681;TMC120; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Herrewege, Y.V.,Michiels, J.,Roey, J.V., et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrobial Agents and Chemotherapy 48(1), 337-339 (2004).
2.Sluis-Cremer, N. and Tachedjian, G. Mechanisms of inhibition of HIV replication by nonnucleoside reverse transcriptase inhibitors. Virus Res. 134(1-2), 147-156 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 329.4 |
| 分子式 | C20H19N5 |
| CAS号 | 244767-67-7 |
| 稳定性 | ≥ 2 years |
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