CGK733
货号：
16242-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16242-1mg |
| 描述 | Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases mediate the DNA damage response pathway in cells upon encounter with genotoxic agents. Their signaling can activate cell cycle arrest, DNA repair, induction of premature senescence, and cell death. Inhibiting this pathway is one strategy implemented to increase the therapeutic capacity of certain genotoxic anti-cancer regimens by sensitizing cancer cells to these agents.1,2 CGK733, a thiourea-containing compound, was originally identified as a specific inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM).1 In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival, resulting in cell death.2 Human cancer cell lines exposed to both caffeine and CGK733 demonstrate a rapid decline in cyclin D1 protein levels and a reduction in retinoblastoma protein levels, which leads to the inhibition of their proliferation.1 |
| 别名 | ATM/ATR Kinase Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Alao, J.P. and Sunnerhagen, P. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat.Oncol. 4, 1-7 (2009).
2.Crescenzi, E.,Palumbo, G.,de Boer, J., et al. Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clinical Cancer Research 14(6), 1877-1887 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 555.8 |
| 分子式 | C23H18Cl3FN4O3S |
| CAS号 | 905973-89-9 |
| 稳定性 | ≥ 2 years |
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