BIX02188
货号：
16238-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16238-1mg |
| 描述 | BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1,800 nM, respectively).1 It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM).1 BIX02188 inhibits phosphorylation of ERK5 in a dose-dependent manner without affecting phosphorylation of ERK1/2, p38 MAPK, or JNK1/2.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tatake, R.J.,ONeill, M.M.,Kennedy, C.A., et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochemical and Biophysical Research Communications 377(1), 120-125 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 412.5 |
| 分子式 | C25H24N4O2 |
| CAS号 | 334949-59-6 |
| 稳定性 | ≥ 2 years |
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