| 货号 | 16159-1mg |
| 描述 | 5-Methyltetrahydrofolic acid is a biologically active form of folic acid that functions, in conjunction with vitamin B12, as a methyl-group donor involved in the conversion of homocysteine to methionine.1,2 The availability of methyl groups is essential for a variety of methylation reactions including the synthesis of DNA and proper neural tube closure.1 It has been used to restore nitric oxide-generating activity in cases of familial hypercholesterolemia or hyperhomocysteinemia, reducing homocysteine levels and improving vascular endothelial function.3,4 |
| 别名 | 5-methyl THF;Prefolic A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Blom, H.J. and Smulders, Y. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J.Inherit.Metab.Dis. 34(1), 75-81 (2011). 2.. 5-Methyltetrahydrofolate. Monograph. Altern.Med.Rev. 11(4), 330-337 (2006). 3.Verhaar, M.C.,Wever, R.M.F.,Kastelein, J.J.P., et al. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 97, 237-241 (1998). 4.Zhang, X.,Li, H.,Jin, H., et al. Effects of homocysteine on endothelial nitric oxide production. American Journal of Physiology.Renal Physiology 279(4), 671-678 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 459.5 |
| 分子式 | C20H25N7O6 |
| CAS号 | 134-35-0 |
| 稳定性 | ≥ 2 years |
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