| 货号 | 16144-1mg |
| 描述 | TTNPB is an analog of retinoic acid (Item No. 11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively).1,2 It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM).2,3 TTNPB is used to study RAR action in diverse processes, including epidermal cell proliferation, embryogenesis, and stem cell differentiation.4,5,6,7 |
| 别名 | AGN 191183;Arotinoid Acid;Ro 13-7410; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beard, R.L.,Chandraratna, R.A.,Colon, D.F., et al. Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. Journal of Medicinal Chemistry 38(15), 2820-2829 (1995). 2.Wong, M.F.,Repa, J.J.,Clagett-Dame, M., et al. Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues. Bioorganic & Medicinal Chemistry Letters 7(17), 2313-2318 (1997). 3.Maloney, P.R.,Parks, D.J.,Haffner, C.D., et al. Identification of a chemical tool for the orphan nuclear receptor FXR. Journal of Medicinal Chemistry 43(16), 2971-2974 (2000). 4.Thacher, S.M.,Standeven, A.M.,Athanikar, J., et al. Receptor specificity of retinoid-induced epidermal hyperplasia: Effect of RXR-selective agonists and correlation with topical irritation. Journal of Pharmacology and Experimental Therapeutics 282(2), 528-534 (1997). 5.Minucci, S.,Saint-Jeannet, J.P.,Toyama, R., et al. Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proceedings of the National Academy of Sciences of the United States of America 93(5), 1803-1807 (1996). 6.Araoka, T.,Mae, S.,Kurose, Y., et al. Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One 9(1), e84881 (2014). 7.Hou, P.,Li, Y.,Zhang, X., et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341(6146), 651-654 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.5 |
| 分子式 | C24H28O2 |
| CAS号 | 71441-28-6 |
| 稳定性 | ≥ 2 years |
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