| 货号 | 16135-50mg |
| 描述 | Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.1,2,3,4 When given intravenously, phentolamine rapidly and transiently increases local blood flow, which has proven useful for the management of hypertensive emergencies.5 Phentolamine also has applications in controlling chronic and emergent pain.6,7 |
| 别名 | Regitine;Vasomax®; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lomasney, J.W.,Cotecchia, S.,Lorenz, W., et al. Molecular cloning and expression of the cDNA for the α1A-adrenergic receptor. The Journal of Biological Chemisty 266(10), 6365-6369 (1991). 2.Millan, M.J.,Newman-Tancredi, A.,Audinot, V., et al. Agonist and antagonist actions of yohimbine as compared to fluparoxan at α2-adrenergic receptors (AR)s, serotonin (5-HT)1A, 5-HT1B, 5-HT1D and dopamine D2 and D3 receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse 35(2), 79-95 (2000). 3.ORourke, M.F.,Iversen, L.J.,Lomasney, J.W., et al. Species orthologs of the Alpha-2A adrenergic receptor: The pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors1. Journal of Pharmacology and Experimental Therapeutics 271(2), 735-740 (1994). 4.Richelson, E. and Nelson, A. Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. Journal of Pharmacology and Experimental Therapeutics 230(1), 94-102 (1984). 5.Varon, J. and Marik, P.E. The diagnosis and management of hypertensive crises. Chest 118(1), 214-227 (2000). 6.Finkel, J.B. and Marhefka, G.D. Rethinking cocaine-associated chest pain and acute coronary syndromes. Mayo Clin.Proc. 86(12), 1198-1207 (2011). 7.Kosharskyy, B.,Almonte, W.,Shaparin, N., et al. Intravenous infusions in chronic pain management. Pain Physician 16, 231-249 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 377.5 |
| 分子式 | C17H19N3O • CH3SO3H |
| CAS号 | 65-28-1 |
| 稳定性 | ≥ 2 years |
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