| 货号 | 16116-1mg |
| 描述 | (±)-Talinolol is a β1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.1 By blocking β1-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity.1 Because its metabolism in human liver microsomes is well understood, (±)-talinolol is useful for examining the activity of the drug-transporting MDR1 gene product P-glycoprotein.2,3,4 |
| 别名 | Cordanum; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Abmann, I. The actions of talinolol, a β1-selectiveβblocker, in cardiac arrhythmia and acute myocardial infarction. Current Medical Research and Opinion 13(6), 325-342 (1995). 2.Trausch, B.,Oertel, R.,Richter, K., et al. Disposition and bioavailability of the β1-adrenoceptor antagonist talinolol in man. Biopharmaceutics & Drug Disposition 16(5), 403-414 (1995). 3.Zschiesche, M.,Lemma, G.L.,Klebingat, K.J., et al. Stereoselective disposition of talinolol in man. Journal of Pharmaceutical Sciences 91(2), 303-311 (2002). 4.Schwarz, U.I.,Seemann, D.,Oertel, R., et al. Grapefruit juice ingestion significantly reduces talinolol bioavailability. Clinical Pharmacology and Therapeutics 77(4), 291-301 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 363.5 |
| 分子式 | C20H33N3O3 |
| CAS号 | 57460-41-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |