| 货号 | 16098-1mg |
| 描述 | Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.1 Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.2 Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.3 DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major metabolite of SFN (Item No. 10496), a powerful inducer of chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression.4,5 At 75 µM, SFN-NAC has been shown to increase ARE expression in HepG2-C8 cells.6 Its reported potency on ARE-related gene expression is roughly 8-fold less than SFN.6 |
| 别名 | SFN-NAC; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wang, R.,Kern, J.T.,Goodfriend, T.L., et al. Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid. Prostaglandins, Leukotrienes and Essential Fatty Acids 81, 53-59 (2009). 2.Gao, L.,Wang, J.,Sekhar, K.R., et al. Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. The Journal of Biological Chemisty 282(4), 2529-2537 (2007). 3.Taguchi, K.,Motohashi, H. and Yamamoto, M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes to Cells 16, 123-140 (2011). 4.Dinkova-Kostova, A.T.,Holtzclaw, W.D.,Cole, R.N., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proceedings of the National Academy of Sciences of the United States of America 99(18), 11908-11913 (2012). 5.Wang, H.,Khor, T.O.,Yang, Q., et al. Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes. Molecular Pharmaceutics 9(10), 2819-2827 (2012). 6.Kim, B.R.,Hu, R.,Keum, Y.S., et al. Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Research 63(21), 7520-7525 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 340.5 |
| 分子式 | C11H20N2O4S3 |
| CAS号 | 334829-66-2 |
| 稳定性 | ≥ 2 years |
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