| 货号 | 16094-10mg |
| 描述 | (−)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively.1,2 It produces biphasic effects on locomotor activity and displays anti-parkinsonian and neuroprotective actions.1,3,4 |
| 别名 | NSC 11442;Uprima; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Millan, M.J.,Maiofiss, L.,Cussac, D., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. Journal of Pharmacology and Experimental Therapeutics 303(2), 791-804 (2002). 2.Seeman, P.,Grigoriadis, D.E. and Niznik, H.B. Selectivity of agonists and antagonists at D2 dopamine receptos compared to D1 and S2 receptors. Drug Development Research 9, 63-69 (1986). 3.Newman-Tancredi, A.,Cussac, D.,Audinot, V., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptor. Journal of Pharmacology and Experimental Therapeutics 303(2), 805-814 (2002). 4.Schechter, M.D.,Rosecrans, J.A. and Glennon, R.A. Comparison of behavioral effects of cathinone, amphetamine and apomorphine. Pharmacology, Biochemistry, and Behavior 20(2), 181-184 (1984). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 303.8 |
| 分子式 | C17H17NO2 • HCl |
| CAS号 | 314-19-2 |
| 稳定性 | ≥ 2 years |
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