TPT-260 (hydrochloride)
货号：
16079-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16079-1mg |
| 描述 | Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM).1 In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.1 |
| 别名 | NSC 55712;R55; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mecozzi, V.J.,Berman, D.E.,Simoes, S., et al. Pharmacological chaperones stabilize retromer to limit APP processing. Nature Chemical Biology (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 333.3 |
| 分子式 | C8H12N4S3 • 2HCl |
| CAS号 | 2076-91-7 |
| 稳定性 | ≥ 2 years |
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