| 货号 | 16067-50mg |
| 描述 | (±)-Muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer, that has found use both in the composition of perfumes and in traditional Chinese medicine practices.1 (±)-Muscone has been shown to exhibit anti-inflammatory effects by reducing the expression of proinflammatory cytokines both in vitroandin vivo. In a model of vertebral end-plate degeneration, 25 µM (±)-muscone was shown to reverse IL-1β-induced upregulation of IL-1β, TNF-α, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide.2 It has also been reported to be both cardioprotective and neuroprotective during conditions of ischemia and to promote proliferation and differentiation of neural stem cells.3,4,5 |
| 别名 | 3-Methylcyclopentadecanone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fujimoto, S.,Yoshikawa, K.,Itoh, M., et al. Synthesis of (R)- and (S)- muscone. Bioscience, Biotechnology, and Biochemistry 66(6), 1389-1392 (2002). 2.Liang, Q.Q.,Zhang, M.,Zhou, Q., et al. Muscone protects vertebral end-plate degeneration by antiinflammatory property. Clin.Orthop.Relat.Res. 468(6), 1600-1610 (2010). 3.Wang, X.,Meng, H.,Chen, P., et al. Beneficial effects of muscone on cardiac remodeling in a mouse model of myocardial infarction. International Journal of Molecular Medicine 34(1), 103-111 (2014). 4.Yu, L.,Wang, N.,Zhang, Y., et al. Neuroprotective effect of muscone on glutamate-induced apoptosis in PC12 cells via antioxidant and Ca2+ antagonism. Neurochemistry International 70, 10-21 (2014). 5.Si, Y.C.,Li, Q.,Xie, C.E., et al. Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells. Chin.Med. 9(1), 13 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 238.4 |
| 分子式 | C16H30O |
| CAS号 | 541-91-3 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |