| 货号 | 16028-100mg |
| 描述 | 3,3,5-Triiodo-L-thyronine (T3) is a thyroid hormone generated by deiodination of the prohormone thyroxine (T4). T3 is a potent agonist of both thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both).1 Through TR signaling, T3 modulates such diverse processes as metabolism, cardiac function, growth, and redox signaling.2,3,4 T3 (sodium salt) is used both in vitroandin vivo to study the action of the TRs.3,4 |
| 别名 | Liothyronine;T3;L-3,3,5-Triiodothyronine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shiohara, H.,Nakamura, T.,Kikuchi, N., et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorganic & Medicinal Chemistry 20(11), 3622-3634 (2012). 2.Cox, M.D.,Dalal, S.S.,Heard, C.R.C., et al. Metabolic rate and thyroid status in rats fed diets of different protein-energy value: The importance of free T3. Journal of Nutrition 114(9), 1609-1616 (1984). 3.Macchia, P.E.,Takeuchi, Y.,Kawai, T., et al. Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α. Proceedings of the National Academy of Sciences of the United States of America 98(1), 349-354 (2001). 4.Videla, L.A.,Cornejo, P.,Romanque, P., et al. Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning. ScientificWorldJournal 2012, 1-11 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 672.3 |
| 分子式 | C15H11I3NO4 • Na |
| CAS号 | 55-06-1 |
| 稳定性 | ≥ 2 years |
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