| 货号 | 15775-10mg |
| 描述 | Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent.1 It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis.2 Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase.3 Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.4 |
| 别名 | BCNU;bis-Chloroethylnitrosourea;Gliadel;NSC 409962; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Burchenal, J.H. and Carter, S.K. New cancer chemotherapeutic agents. Cancer 30(6), 1639-1646 (1972). 2.Wasserman, T.H.,Slavik, M. and Carter, S.K. Clinical comparison of the nitrosoureas. Cancer 36(4), 1258-1268 (1975). 3.Arscott, L.D.,Gromer, S.,Schirmer, R.H., et al. The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase for Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 94, 3621-3626 (1997). 4.Zhang, Y.D.,Dai, R.Y.,Chen, Z., et al. Efficacy and safety of carmustine wafers in the treatment of glioblastoma multiforme: A systematic review. Turk.Neurosurg. 24(5), 639-645 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 214.1 |
| 分子式 | C5H9Cl2N3O2 |
| CAS号 | 154-93-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |