Pelitinib
货号：
15627-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 15627-1mg |
| 描述 | Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM).1 It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM).1 By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).2 |
| 别名 | EKB-569; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Arkin, M. and Moasser, M.M. HER2 directed small molecule antagonists. Curr.Opin.Investig.Drugs 9(12), 1264-1276 (2008).
2.Kim, H. and Lim, H.Y. Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. J.Korean Med.Sci. 26(12), 1563-1568 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 467.9 |
| 分子式 | C24H23ClFN5O2 |
| CAS号 | 257933-82-7 |
| 稳定性 | ≥ 2 years |
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