| 货号 | 15625-5mg |
| 描述 | Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM).1,2,3 It has been shown to inhibit the release of leukotriene C4(IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg.4 |
| 别名 | Claritin®;SCH 29851; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ahn, H.S. and Barnett, A. Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. European Journal of Pharmacology 127(1-2), 153-155 (1986). 2.Kay, G.G. and Harris, A.G. Loratadine: A non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clinical and Experimental Allergy 29, 147-150 (1999). 3.Barnett, A.,Iorio, L.C.,Kreutner, W., et al. Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents and Actions 43(3-4), 149-156 (1994). 4.Kreutner, W.,Chapman, R.W.,Gulbenkian, A., et al. Antiallergic activity of loratadine, a non-sedating antihistamine. Allergy 42(1), 57-63 (1987). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 382.9 |
| 分子式 | C22H23ClN2O2 |
| CAS号 | 79794-75-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |