| 货号 | 15577-1mg |
| 描述 | The P2X purinergic receptors are ligand-gated ion channels that are activated by extracellular ATP. BzATP (ammonium salt) is an activator of the P2X receptors that exhibits 5-30-fold greater potency at the P2X7 receptor than ATP.1,2,3 It activates the human, rat, and mouse receptors with EC50 values of 0.7, 3.6, and 285 μM, respectively.4 BzATP is not selective for P2X7 as it can potently activate other P2X receptors, but without the marked superiority to ATP as an agonist.1,2,5 BzATP can also be used as a photoaffinity probe to study adenine nucleotide binding to ATPases.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Anderson, C.M. and Nedergaard, M. Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends in Neurosciences 29(5), 257-262 (2006). 2.Bianchi, B.R.,Lynch, K.J.,Touma, E., et al. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. European Journal of Pharmacology 376(1-2), 127-138 (1999). 3.Michel, A.D.,Xing, M. and Humphrey, P.P. Serum constituents can affect 2-& 3-O-(4-benzoylbenzoyl)-ATP potency at P2X7 receptors. British Journal of Pharmacology 132(7), 1501-1508 (2001). 4.Young, M.T.,Pelegrin, P. and Surprenant, A. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Molecular Pharmacology 71(1), 92-100 (2007). 5.Zhong, Y.,Dunn, P.M.,Xiang, Z., et al. Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. British Journal of Pharmacology 125(4), 771-781 (1998). 6.Williams, N. and Coleman, P.S. Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3-O-(4-benzoyl)benzoyl adenosine 5-triphosphate. The Journal of Biological Chemisty 257(6), 2834-2841 (1982). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 732.4 |
| 分子式 | C24H24N5O15P3 • NH4+ |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |